Regulated trafficking of the CFTR chloride channel
نویسندگان
چکیده
منابع مشابه
Regulation of CFTR chloride channel trafficking by Nedd4-2: role of SGK1
Introduction: The cystic fibrosis transmembrane conductance regulator (CFTR) chloride (Cl−) channel is an essential component of epithelial Cl− transport systems in many organs. CFTR is mainly expressed in the lung and other tissues, such as testis, duodenum, trachea and kidney. The ubiquitin ligase neural precursor cells expressed developmentally down-regulated protein 4-2 (Nedd4-2...
متن کاملregulation of cftr chloride channel trafficking by nedd4-2: role of sgk1
introduction: the cystic fibrosis transmembrane conductance regulator (cftr) chloride (cl−) channel is an essential component of epithelial cl− transport systems in many organs. cftr is mainly expressed in the lung and other tissues, such as testis, duodenum, trachea and kidney. the ubiquitin ligase neural precursor cells expressed developmentally down-regulated protein 4-2 (nedd4-2) has previo...
متن کاملPermeation through the CFTR chloride channel.
The cystic fibrosis transmembrane conductance regulator (CFTR) protein forms a Cl(-) channel found in the plasma membranes of many epithelial cells, including those of the kidney, gut and conducting airways. Mutation of the gene encoding CFTR is the primary defect in cystic fibrosis, a disease that affects approximately 30 000 individuals in the United States alone. Alteration of CFTR function ...
متن کاملPharmacology of CFTR chloride channel activity.
Pharmacology of CFTR Chloride Channel Activity. Physiol. Rev. 79, Suppl.: S109-S144, 1999. - The pharmacology of cystic fibrosis transmembrane conductance regulator (CFTR) is at an early stage of development. Here we attempt to review the status of those compounds that modulate the Cl- channel activity of CFTR. Three classes of compounds, the sulfonylureas, the disulfonic stilbenes, and the ary...
متن کاملThe role of regulated CFTR trafficking in epithelial secretion.
The focus of this review is the regulated trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in distal compartments of the protein secretory pathway and the question of how changes in CFTR cellular distribution may impact on the functions of polarized epithelial cells. We summarize data concerning the cellular localization and activity of CFTR and attempt to synthesiz...
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ژورنال
عنوان ژورنال: European Journal of Cell Biology
سال: 2000
ISSN: 0171-9335
DOI: 10.1078/0171-9335-00078